Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia

Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties.

The extract produced an inhibition of carrageenan-induced edema in the rat paw over a dose range of 10-300 mg/kg i.p.; the dose-response curve was bell-shaped with a maximal effect at 100 mg/kg. The extract also produced a small but significant increase in the response latency of rats subjected to the hot plate, a thermal pain test that only detects analgesia by high-efficacy agents. The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans

Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties. The extract produced an inhibition of carrageenan-induced edema in the rat paw over a dose range of 10-300 mg/kg i.p.; the dose-response curve was bell-shaped with a maximal effect at 100 mg/kg.

The extract also produced a small but significant increase in the response latency of rats subjected to the hot plate, a thermal pain test that only detects analgesia by high-efficacy agents. The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans The principal factor for intoxication to occur is related to feeding on pastures with the presence of some toxic variety of L. camara.

The toxic effects of the leaves have usually been attributed to a series of pentacyclic triterpenes, in which lantadenes A and B are typical members (Sharma et al., 1988). The nontoxic species do not contain these lantadenes or possess them in low quantities.

Species of genus Lantana are plants practically immune to attack by herbivores, due to the presence of a great diversity of secondary metabolites (Kohli et al., 2006). They also have anti-rheumatic, stimulant and sudorific properties, and are used to treat broncho-pulmonary disorders, and some species are utilized in biological control as a pesticide (Ghisalbert, 2000; Dua et al., 2003; 2010). Organic extracts and essential oils of Lantana have shown a wide variety of biological and pharmacological activities.

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